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KMID : 0811720130170010037
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Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 1 p.37 ~ p.42
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Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene K+ Channels
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Yun Ji-Hyun
Bae Hye-Mi
Choi Sun-Eun
Kim Jung-Ha
Choi Young-Wook
Lim In-Ja
Lee Chung-Soo
Lee Min-Won
Ko Jae-Hong
Seo Seong-Jun
Bang Hyo-Weon
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Abstract
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Taxifolin glycoside is a new drug candidate for the treatment of atopic dermatitis (AD). Many drugs cause side effects such as long QT syndrome by blocking the human ether-a-go-go related gene (hERG) K+ channels. To determine whether taxifolin glycoside would block hERG K+ channels, we recorded hERG K+ currents using a whole-cell patch clamp technique. We found that taxifolin glycoside directly blocked hERG K+ current in a concentration-dependent manner (EC50=9.6±0.7?M). The activation curve of hERG K+ channels was negatively shifted by taxifolin glycoside. In addition, taxifolin glycoside accelerated the activation time constant and reduced the onset of the inactivation time constant. These results suggest that taxifolin glycoside blocks hERG K+ channels that function by facilitating activation and inactivation process.
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KEYWORD
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hERG K+ channel, Long QT syndrome, Patch clamp, Taxifolin glycoside
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